10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer

نویسندگان

  • F. C. Hamdy
  • J. L. Donovan
  • J. A. Lane
  • M. Mason
  • C. Metcalfe
  • P. Holding
  • M. Davis
  • T. J. Peters
  • E. L. Turner
  • R. M. Martin
  • J. Oxley
  • M. Robinson
  • J. Staffurth
  • E. Walsh
  • P. Bollina
  • J. Catto
  • A. Doble
  • A. Doherty
  • D. Gillatt
  • R. Kockelbergh
  • H. Kynaston
چکیده

METHODS We compared active monitoring, radical prostatectomy, and external-beam radiotherapy for the treatment of clinically localized prostate cancer. Between 1999 and 2009, a total of 82,429 men 50 to 69 years of age received a PSA test; 2664 received a diagnosis of localized prostate cancer, and 1643 agreed to undergo randomization to active monitoring (545 men), surgery (553), or radiotherapy (545). The primary outcome was prostate-cancer mortality at a median of 10 years of follow-up. Secondary outcomes included the rates of disease progression, metastases, and all-cause deaths.

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تاریخ انتشار 2016